• Many studies are poorly designed in order to promote an agenda.
• Replicating results is necessary for good science, but rare
• Peer review has many shortcomings
• Too much science is locked behind paywalls
• Intellectual Property is slowing down science and creating inequalities

The pharmaceutical industry is a massive global business, worth billions of dollars each year. It is made up of numerous companies that develop, manufacture, and market drugs and medical devices. Corporate interests play a significant role in the pharmaceutical industry, as these companies are driven by the need to make a profit. This profit motive can sometimes conflict with public health interests.

Getting funding and conflicts of interest: 

One of the biggest challenges for medical scientists is to find a sustainable source of funding. In most places around the world, Governments or public organizations provide funding for medical research, reducing the chances of conflicts of interest, however, these are limited funds. This means researchers look for private funding that supports science aligning with their corporate agenda. This is catastrophic because it means that some science is guided not by what is good for society/humanity, but by what will make the most return on investment to these private funders. Much of nutrition science is funded by the food industry, and this is a major conflict of interest. Food companies will not alter the results of research, however, they will not fund something if the hypothesis goes against their interests, thus shaping how science evolves.^{1 2}

Only around 1% of newly developed drugs in the late 20th century were for tropical diseases like African sleeping sickness, dengue fever, and leishmaniasis. As a result, only a single new drug has been introduced in the past 50 years to treat tuberculosis, which claims the lives of millions of people each year.³ This is because research done by pharmaceutical companies is often focused on profitable markets. This means a significant portion of healthcare spending is on drugs to treat conditions like type 2 diabetes, hypertension, and high cholesterol, which are largely caused by poor diets and a lack of exercise. Implementing policies like stricter regulations on unhealthy foods and drinks, subsidized healthy school meals, and courses on preparing nutritious and affordable meals can help people lose weight, lowering the need for these drugs. 

Since scientists have to compete for this finite and decreasing amount of funding (at least for public funding), it creates conflicts of interest between scientists of the same field, puts pressure to publish many papers instead of a few quality ones, and forces scientists to oversell their work (use buzzwords to get funding). This competition between scientists for funding affects what people study, the risks they take, and the risks they don’t take. Overall it pushes researchers to do predictable, safe, and hyped science. On top of that, grants are usually short-term (3-5 years), which means that scientists are less likely to apply for long-term projects, even though these are usually the ones that create the biggest discoveries. All this pushes scientists to submit repetitive, short, safe studies. 

Repetitive results and lack of truth and transparency: 

Medical researchers are judged by the research they publish, and they have tons of pressure to get certain types of results. If you get good splashy results, it will be easier to get published in a prestigious journal, but if they get mediocre results, many scientists consider presenting the data differently to keep it exciting. “The consequences are staggering. An estimated $200 billion — or the equivalent of 85 percent of global spending on research — is routinely wasted on poorly designed and redundant studies, according to meta-researchers who have analyzed inefficiencies in research. We know that as much as 30 percent of the most influential original medical research papers later turn out to be wrong or exaggerated.”⁴

The crisis of irreproducibility: 

A survey made by nature.com (1576 researchers) claims that there is a “crisis of irreproducibility”. It concludes that “70% of researchers have tried and failed to reproduce another scientist’s experiments, and more than half have failed to reproduce their own experiments.”^{5 6}

Additionally, studies that fail to replicate results from a “good” study might not get published, thus creating bias in science (rejected publications may have value). Some causes could be a lack of understanding of statistics, poor experimental design, lack of mentoring from senior researchers, fraud, hyper-competition, lack of resources, or simply selective reporting of results.

Science is behind paywalls: 

Science and research is mostly locked away and not easily accessible. They are often costly to access and can be hard to find. Many researchers have argued that academic research should be free for all to access, as many for-profit publishers slow down the pace of science. One article in a scientific journal can cost you 30$, some yearly subscriptions are 300$ and up to 10,000$.⁷ On top of publishing fees paid by the research team.⁸

Science is slowed and locked by intellectual property: 

*This will be the longest section as it is arguably the most important thing to change in the way we do medical research. 

Protected patents are a relatively recent invention, the first modern patent system was created in 1474  in Venice, and it has since evolved into a complex set of laws and regulations, both at the local and international levels.⁹ Despite the fact that patents are intended to promote innovation and progress, their impact on the development and access to life-saving drugs has been a subject of increasing concern. The current patent system, which grants exclusive rights to pharmaceutical companies to produce and sell drugs, has led to high medicine prices, limited the scope of research, and limited access to care for many people, especially those in developing countries.¹⁰

Is the right to intellectual property or Human rights more important to you? I believe that patents should not extend so far as to interfere with individuals’ dignity and well-being. Where patent rights and human rights are in conflict, human rights must prevail.

The current system allows pharmaceutical companies to patent new drugs and prevent other companies from manufacturing and selling generic versions of those drugs for a fixed period of time, usually around 20 years. This gives the patent holder a monopoly on using, producing, importing, and selling the drug, which allows them to charge high prices to recoup their research and development costs and make a profit.¹¹

It also prevents researchers from sharing their ideas and promotes wasteful practices. Ironically, stronger patent protection may even lead to less innovation. When patents expire, drug companies frequently sue competitors to prevent them from selling cheaper generic versions. The European Commission estimated that these legal battles had cost the EU €3 billion over an 8-year period.¹²

Before the mid-1990s, pharmaceutical product patents were not permitted in many developing nations (India is a prime example). This decision was often a deliberate policy choice, based on the belief that the advantages of low-cost access to medication outweighed any potential negative consequences resulting from the absence of domestic patents on multinational companies’ research and development decisions. However, since the World Trade Organization’s adoption of the Trade-Related Intellectual Property Rights (TRIPs) agreement in 1995, all countries have been required to allow pharmaceutical product patents. TRIPS has been controversial, as it can make it difficult for developing countries to produce or import affordable generic versions of patented medicines. According to the World Bank: “Nothing is more controversial in TRIPS. […] Many developing countries see little potential benefit from introducing patents. In contrast, potential costs could be significant.”¹³

“Like a poorly conceived new drug with deadly side effects, the modern medicine patent regime is a relatively recent innovation and, not a good one.”¹⁴

Overall, the flaws of the patent system: 

1. Patent monopolies allow pharmaceutical companies to charge exorbitant prices for essential medicines. This can make them unaffordable for many people, particularly those in developing countries who cannot afford to pay high prices for life-saving treatments.
2. The high cost of drug development is often used as an argument to justify high drug prices, but the actual cost of drug development is often overstated. Pharmaceutical companies often spend more money on marketing and lobbying efforts than they do on research and development. Independent analysts have estimated the cost of developing a new drug to be significantly lower than the industry’s claim of around US $1 billion, and the Drugs for Neglected Diseases Initiative (DNDi) believes they can develop a new drug for $110 million to $170 million. These costs include a theoretical expense for failed projects. Ultimately, drug prices do not reflect research and development expenses but rather what heavily subsidized “markets” are willing to pay. Making private insurance more expensive, as well as government-supported healthcare thus wasting tax money.¹⁵
3. Pharmaceutical companies can extend their patent protection by making minor changes to a drug or by obtaining multiple patents on the same drug. This practice, known as “evergreening,” can extend a drug’s patent protection for years and prevent the development of generic versions. The strategic value of patents has expanded beyond their role in promoting innovation. Even if a patent does not generate revenue, it can still be highly valuable for its strategic benefits. Using a patent as a blocking strategy is common practice. ¹⁶
4. The current patent system does not incentivize the development of medicines for neglected diseases that primarily affect people in developing countries. This is because there is often little profit to be made in developing treatments for these diseases.

Must read papers to understand the cost of patents: “Deadly gaps in the patent system : an analysis of current and alternative mechanisms for incentivising development of medical therapies.”¹⁷, “Are Patents Really Necessary?”¹⁸ and this incredible meta study. ¹⁹

What is Etica Protocol: 

It is an open-source protocol for medical research without intellectual property. It aims to create an alternative funding solution for medical research while removing patents. Researchers are financially rewarded throughout the process of research, and all solutions found within Etica are immediately available for anyone to use. Open Source has already proven to be faster and more efficient in many other fields like Software development (such as AI research) and can fundamentally change how we do medical research.

Grant proposals are grouped by disease on Etica.io, and then users (holders of ETI) can vote and get rewarded for correctly participating. In the long term, Etica.io will be only one of potentially thousands of websites connected to the Etica blockchain. Potentially, instead of having science locked in journals with paywalls, we could have websites directly connected to the Etica blockchain, without restriction and free of patent. To that extent Etica blockchain can be called a permissionless decentralised science journal.

How can Etica solve problems with modern medical research: 

• The big money problem: Etica provides a new additional decentralized funding system for medical researchers to use. We are not naive, most people will act for their own interest. Etica is not under the control of the incumbent of the system that chooses the pace and direction of research according to their vested interest.
• Poorly designed studies, and reproducibility: It will be important for the community to select quality and not flashy research. In fact the token holders have a collective interest that Etica maintains its value. If the network globally accepts unqualified/useless proposals then the network is going to become worthless. A key part of the Etica system is that the token holders have a responsibility to get the best proposals rewarded so that people keep increasing the amount of work they do for each proposal and create a healthy open-source ecosystem.
• Paywalls: All Etica proposals are public and free to read, uploaded on the IFPS network, as well as easy to access.
• Intellectual property: Etica removes intellectual property which is costly to medical research and human rights.

Etica enables people to “donate” / invest money in open-source medical research. You can earn rewards by deciding what will get funded, and it is always possible to cash out ETIs. The current model is funded by the government (taxes, public health insurance) or private insurance often colluding and price-fixing with pharma companies funding mostly useless overpriced science. We are currently paying taxes, or insurance to solve hair loss problems, instead of focusing on  life-saving research. With Etica, it is possible to self-fund open medical research, all while protecting your money in a low-inflation asset.

1. https://www.vox.com/2016/3/3/11148422/food-science-nutrition-research-bias-conflict-interest ︎
2. https://pubmed.ncbi.nlm.nih.gov/12928469/ ︎
3. https://www.hhrjournal.org/2015/11/making-medicines-accessible-alternatives-to-the-flawed-patent-system-2/ ︎
4. https://www.vox.com/2016/7/14/12016710/science-challeges-research-funding-peer-review-process ︎
5. https://www.nature.com/articles/533452a ︎
6. https://www.science.org/doi/10.1126/science.aac4716 ︎
7. https://www.theguardian.com/commentisfree/2011/aug/29/academic-publishers-murdoch-socialist ︎
8. https://www.enago.com/academy/what-is-the-real-cost-of-scientific-publishing/ ︎
9. https://papers.ssrn.com/sol3/papers.cfm?abstract_id=585661 ︎
10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636619/ ︎
11. https://onlinelibrary.wiley.com/doi/full/10.1111/1758-5899.12730 ︎
12. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817403/ ︎
13. https://documents1.worldbank.org/curated/en/285571468337817024/310436360_20050012014722/additional/Global-economic-prospects-and-the-developing-countries-2002-making-trade-work-for-the-worlds-poor.pdf ︎
14. https://www.hhrjournal.org/2015/11/making-medicines-accessible-alternatives-to-the-flawed-patent-system-2/ ︎
15. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817403/ ︎
16. https://onlinelibrary.wiley.com/doi/full/10.1111/1758-5899.12730 ︎
17. https://ir.canterbury.ac.nz/bitstream/handle/10092/9826/thesis_fulltext.pdf?isAllowed=y&sequence=1 ︎
18. https://www.cigionline.org/articles/are-patents-really-necessary/ ︎
19. https://globalizationandhealth.biomedcentral.com/articles/10.1186/s12992-022-00826-4 ︎

ChimiaDAO research. Voters are more harsh proposals.

A second proposal from the same address on a similar subject. Had already done: Non-Drug approaches in healthcare: phytotherapy

A guy name Cez – let’s see some results – Once again – the vote is yours

Comment on telegram/discord(general chat):

“Yes I totally agree with you and I know that the research needs be improved and go further. We are still at stage 1 ! The second phase of the study will entail quantitative analysis as well as an experimental set up. I see this first phase as an in-depth topic discussion with the community, hoping that people show interest for it, and perhaps for those interested, propose different non-drug approaches in healthcare in order to widen our scope”

An Enhanced Protocol for the Diagnosis and Treatment of UARS Patients Using Positive Airway Pressure

Mysterious poster but an interesting proposal. Not spam thus vote like you want. https://etica.io/app/main/proposal?proposalhash=0x840a41d9cadd2a2c66bfba0b00ba5513f8f11b10e6b80f6ad98c803652c22c55

Some other important comments:

ZW on telegram: “The public can vote according to their will. There will be a balance between the professional peer-reviewers and the public.” A very interesting message from him that highlights one of the advantages of the Etica protocol.

“Since I mentioned the use of language, I will briefly explain it. In professional research article, any exaggeration, unnecessary adjectives are strictly prohibitied. Any results or discussions are stated plainly in a serious tone as facts in order to look professional.” added by ZW

“For a follow-up study (This is different from the initial proposal). We expect results to be published at least partially. On ETICA, the sharing of open-source research data and results is its goal. If no experiment is perfomed, and no results published. How do we evaluate the effectiveness of the follow-up study? It adds no value to the blockchain. The study is therefore better terminated.”

“The demonstration of research progress is key for the continuation of follow-up studies. Without any mention of the experimental setup, its partial results, there is no way for the reviewer to judge the quality of research nor its feasibility.”

“Eventually, ETICA need to surpass this level of quality. AND also provide open access to results. Not saying it has to reach this level now. But needs to at least show some effort. Having absolutely no results is not great”

“Decoding Research: Navigating the Landscape of Scientific Publications”

First of all: Thank you @zyxtina on Discord and telegram, or Cris for writing this.

Here we go a good start – # Guide to Scientific Publications

Introduction

Welcome to the world of scientific publications! This document serves as a comprehensive guide to the diverse range of scientific publication types, intended for a technically adept audience eager to understand and possibly contribute to the field of scientific research. The aim is to demystify the formats, purposes, and processes of different publications, making the realm of scientific discourse more accessible and engaging.

Types of Scientific Publications

1. Original Research Articles

These are detailed reports presenting original and novel findings. They are fundamental to the progression of science, allowing researchers to share new insights and discoveries. Typically, they include sections such as introduction, methodology, results, and discussion.

2. Review Articles

Review articles provide a summarization and critical evaluation of existing literature on a specific topic. They synthesize findings from various studies, offering a comprehensive overview and understanding of the area of research.

3. Short Communications

Short communications are brief descriptions of significant current research findings. They are quicker to publish than full research articles, allowing researchers to disseminate important results promptly.

4. Case Reports

Case reports detail specific instances of interesting or rare occurrences in a clinical or research setting. They are valuable in medical fields as they can unveil new types of diseases, treatment outcomes, or rare findings.

5. Letters and Commentaries

Letters are short descriptions of research findings or critical comments on published articles. Commentaries are usually opinion pieces written by senior researchers discussing the implications of a specific study or topic.

6. Conference Proceedings

These are collections of papers or posters presented at academic conferences. They include cutting-edge research and are often the first place new research is publicly presented.

7. Technical Reports

Produced mainly by governmental agencies or specific institutions, technical reports detail the progress or results of scientific or technical research and are often not subject to peer review.

8. Theses and Dissertations

These are detailed documents submitted in pursuit of an academic degree, representing the author’s research and findings in their field of study.

Conclusion

This guide is intended to be a dynamic resource, evolving with contributions from the community to stay relevant and up-to-date. Understanding the landscape of scientific publications not only aids in consuming scientific content but also empowers individuals to contribute effectively to the expanding body of knowledge. Whether you’re a novice reader, an aspiring researcher, or a seasoned scientist, grasping the nuances of these publications is key to navigating the vast sea of scientific information. // thank you ChimiaResearch GPT needs much more but at least a start, I need to sleep, have a lovely day or night, everyone

This proposal was posted by ChimiaDAO governed by Cris at the moment. We know his identity, and has shared messages on telegram and discord. Sadly, due to a mistake, the proposal was submitted twice. Please systematically refuse the first one. And feel free to vote as you like on the “real” proposal.

It is a great follow up to proposals already posted on Etica.io, showing how we can collaborate to find solutions. This is a very interesting proposal that shows promise and if accepted will require tracking but hopefully we will get some interesting useful results from this.

From Geistluchs: ChimiaDAO has a great website and is the first “real” research project on Etica. Hope it will be successful in the future. Thank you

This article got a lot of controversy in the telegram group chat. And started a conversation on double publication and either it should be done. The author of this paper “frank” is known by the community, and has reached out to etica protocol community member. The funding would go towards future research on the same subject.

A community member (No body on telegram) has shared this: “It is undeniable that the author of the proposal is respected researcher in leading European university conducting studies on regenerative neuroscience related to CDNF in ALS True pianer in the field. It’s great to start noticing Etica. But for the the community, to ensure Etica’s decentralization, fair voting, and healthy development. We hope that everyone in the community can veto this proposal after careful consideration. Similarly, we hope that the community member who is the author does not feel sad or upset about it. Every one in the community greatly appreciate your support, but we also believe you can understand the significance of our veto. We are all making Etica better.”

Anyways, Etica memeber have the right to vote either way they want, but here is a remimder on suggested guidelines: https://eticaintel.org/2023/11/13/what-is-a-good-proposal-voting-guidelines-for-etica-protocol/

Non-Drug approaches in healthcare: phytotherapy

This proposer wants to use proposal funds to start researching non drug approach for medication. The Proposal is readable and has sources. Overall this is a fine proposal and it is your choice to vote. We don’t know the identity of the proposer.

Isolation and societal separation lead to suicidal, self-harm, and other lesser desired mental states creating a serious concern

No IFPS, just a description: “In the United States alone, 153 successful suicides occur each day. Every year 703 000 people take their own life and there are many more people who attempt suicide. Every suicide is a tragedy that affects families, communities and entire countries and has long-lasting effects on the people left behind. This proposal intends to perform the necessary research to understand the true impact to the future of humanity and if this surge in isolation and societal separation will continue as a result of technological advancements such as AI.”

This does not feel enough to get accepted for a proposal. This person should think to redo the proposal with a more precise plan in the IFPS.

Breast cancer survivors experience a significant drop in libido aka sexual appetite

Are twelve step programs the most successful avenue to cure addition?

Both these proposal were done by this proposer: https://www.eticascan.org/address/0x5Ae913C0dCdfb678615A53e927e7E1f9871beC2C

Not enough to get funding in my opinion.

Can Lack of Sleep Cause Baldness?

Miguel Jordan has posted another proposal. New adress but same author: https://www.eticascan.org/address/0xAB55c5B9a4Dec76Fd371C471E0F5cDFC83E0E24D Once again, no sources, and little added value to the Etica ecosystem.

The Effectiveness of Intermittent Fasting

The IFPS downloads a word document, the content has sources and the english is good but the quality of the research is low. Thank you, Seth Tsang to have posted a proposal on Etica. Hope to see more in the future.